Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6541024

Title:Regeneration and augmentation of bone using mesenchymal stem cells
Inventors:Kadiyala, Sudhakar; Baltimore, MD, USA
Bruder, Scott P.; Owings Mills, MD, USA
Summary:This invention introduces methods of regeneration and augmentation of bone via mesenchymal stem cells and a medium which supports their differentiation into osteogenic cells. The invention relates to compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix, fresh, whole marrow, or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Further disclosed are methods of delivery for such hMSCs and for freshly aspirated bone marrow, separately or combined. Therapeutic applications to the treatment of patients in need thereof are included.
Abstract:Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6541024
Application Number:US1998000042275
Date Filed:13/03/1998
Date Published:01/04/2003
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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