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Stem Cell Related Patent Number US6541212
| Title: | Methods for detecting prostate stem cell antigen protein | | Inventors: | Reiter, Robert E.; Los Angeles, CA, USA | | Summary: | Described herein are antibodies binding to the prostate stem cell antigen protein which inhibit the growth of cancer cells. The invention relates to a prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. Further disclosed is a method by which the PSCA protein of bone (SEQ ID NO:2) is detected, via contacting a sample with an antibody that recognizes and binds the PSCA protein, which is followed by a method of detection for the binding of the antibody with the PSCA protein in the sample. Therapeutic applications in the detection and treatment of prostate, pancreatic and bladder cancers are provided. | | Abstract: | The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. The invention also provides a method for detecting a Prostate Stem Cell Antigen (PSCA) protein of bone (SEQ ID NO:2), comprising obtaining a sample; contacting the sample with an antibody that recognizes and binds the PSCA protein; and, detecting binding of the antibody with the PSCA protein in the sample. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6541212 | | Application Number: | US2000000564329 | | Date Filed: | 03/05/2000 | | Date Published: | 01/04/2003 | | Assignee: | The Regents of the University of California, Oakland, CA, USA |
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