Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6541212

Title:Methods for detecting prostate stem cell antigen protein
Inventors:Reiter, Robert E.; Los Angeles, CA, USA
Summary:Described herein are antibodies binding to the prostate stem cell antigen protein which inhibit the growth of cancer cells. The invention relates to a prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. Further disclosed is a method by which the PSCA protein of bone (SEQ ID NO:2) is detected, via contacting a sample with an antibody that recognizes and binds the PSCA protein, which is followed by a method of detection for the binding of the antibody with the PSCA protein in the sample. Therapeutic applications in the detection and treatment of prostate, pancreatic and bladder cancers are provided.
Abstract:The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. The invention also provides a method for detecting a Prostate Stem Cell Antigen (PSCA) protein of bone (SEQ ID NO:2), comprising obtaining a sample; contacting the sample with an antibody that recognizes and binds the PSCA protein; and, detecting binding of the antibody with the PSCA protein in the sample.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6541212
Application Number:US2000000564329
Date Filed:03/05/2000
Date Published:01/04/2003
Assignee:The Regents of the University of California, Oakland, CA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021