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Stem Cell Related Patent Number US6558663
| Title: | Transgenic swine & swine cells having human HLA genes | | Inventors: | Seebach, Joerg; Boston, MA, USA
Sachs, David H.; Newton, MA, USA
DerSimonian, Harout; Wellesley, MA, USA
LeGuern, Christian; Newton, MA, USA | | Summary: | Described herein are new genetically engineered swine cells which include human lymphocytic antigen HLA A, HLA B, HLA C or HLA G genes. The invention relates to methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient of a swine graft. Claims of the invention include methods by which a swine hematopoietic stem cell, which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack, is introduced into a human recipient to inhibit recipient natural killer cell mediated attack. Therapeutic applications for promoting immunologic tolerance are included. | | Abstract: | Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic stem cell which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6558663 | | Application Number: | US1999000457177 | | Date Filed: | 08/12/1999 | | Date Published: | 06/05/2003 | | Assignee: | The General Hospital Corporation, Boston, MA, USA |
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