Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6558663

Title:Transgenic swine & swine cells having human HLA genes
Inventors:Seebach, Joerg; Boston, MA, USA
Sachs, David H.; Newton, MA, USA
DerSimonian, Harout; Wellesley, MA, USA
LeGuern, Christian; Newton, MA, USA
Summary:Described herein are new genetically engineered swine cells which include human lymphocytic antigen HLA A, HLA B, HLA C or HLA G genes. The invention relates to methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient of a swine graft. Claims of the invention include methods by which a swine hematopoietic stem cell, which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack, is introduced into a human recipient to inhibit recipient natural killer cell mediated attack. Therapeutic applications for promoting immunologic tolerance are included.
Abstract:Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic stem cell which has been transformed with a transgene encoding a human MHC class I protein that inhibits recipient NK cell mediated attack.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6558663
Application Number:US1999000457177
Date Filed:08/12/1999
Date Published:06/05/2003
Assignee:The General Hospital Corporation, Boston, MA, USA


 
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