Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6562956

Title:Identification and cloning of a new subfamily of sulfatases and functional embryonic techniques for characterization of such proteins
Inventors:Emerson, Charles P.; Bala Cynwyd, PA, USA
Dhoot, Gurtej Kaur; London, United Kingdom
Summary:This invention describes novel members of a new subfamily of sulfatases termed Sulf-1 and Sulf-2 polypeptides, methods and uses thereof. Described herein are nucleic acid sequences encoding members of the new subfamily as well as compositions and methods of modulating the sulfatases of this new subfamily . Further disclosed are methods by which such modulation may modify growth properties and the differentiation of cells, as well as the ability of cells to prevent viral entry and to prevent recruitment of lymphocytes to a site of inflammation . Therapeutic applications are included, such as in the treatment of cancer and inhibiting metastases, in the promotion of the differentiation of stem cells into muscle, neural and renal cells and in the inhibition of viral infection and inflammation. Further provided are functional embryonic techniques for the identification and characterization of developmental regulatory genes such as these sulfatases.
Abstract:Nucleic acid sequences encoding members of a new subfamily of sulfatases and polypeptides encoded thereby are provided. Compositions and methods of modulating sulfatases of this new subfamily to modify growth properties and differentiation of cells, as well as the ability of cells to prevent viral entry and to prevent recruitment of lymphocytes to a site of inflammation are also provided. The compositions and methods are useful in treating cancer and inhibiting metastases, promoting differentiation of stem cells into muscle, neural and renal cells and inhibiting viral infection and inflammation. In addition, functional embryonic techniques for identification and characterization of developmental regulatory genes such as these sulfatases are provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6562956
Application Number:US2000000668673
Date Filed:22/09/2000
Date Published:13/05/2003
Assignee:Trustees of the University of Pennsylvania, Philadelphia, PA, USA The Royal Veterinary College, London, United Kingdom


 
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