Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6565827

Title:Radioimmunotherapy of lymphoma using anti-CD20 antibodies
Inventors:Kaminski, Mark S.; Ann Arbor, MI, USA
Butchko, Gregory M.; Lake Forest, IL, USA
Glenn, Stephan D.; Sunnyvale, CA, USA
Wahl, Richard L.; Ann Arbor, MI, USA
Summary:This invention describes a novel composition comprising a radioactively labeled monoclonal antibody or its fragment. The invention relates to methods by which such a composition is administered in the presence of a pharmaceutically acceptable carrier to provide preset irradiation to the whole body of a human patient in order to achieve remission of B-cell lymphoma. Further disclosed are methods by which a patient is provided both with unlabeled antibodies and with antibodies labeled with a radioisotope. Claims of the invention include tumor responses which can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy. Further therapies in the treatment of non-Hodgkin's disease are included.
Abstract:Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6565827
Application Number:US2001000924360
Date Filed:07/08/2001
Date Published:20/05/2003
Assignee:Coulter Pharmaceutical, Inc., South San Francisco, CA, USA The Regents of the University of Michigan, Ann Arbor, MI, USA Coulter Pharmaceutical, Inc., South San Francisco, CA, USA The Regents of the University of Michigan, Ann Arbor, MI, USA


 
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