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Stem Cell Related Patent Number US6565827
| Title: | Radioimmunotherapy of lymphoma using anti-CD20 antibodies | | Inventors: | Kaminski, Mark S.; Ann Arbor, MI, USA
Butchko, Gregory M.; Lake Forest, IL, USA
Glenn, Stephan D.; Sunnyvale, CA, USA
Wahl, Richard L.; Ann Arbor, MI, USA | | Summary: | This invention describes a novel composition comprising a radioactively labeled monoclonal antibody or its fragment. The invention relates to methods by which such a composition is administered in the presence of a pharmaceutically acceptable carrier to provide preset irradiation to the whole body of a human patient in order to achieve remission of B-cell lymphoma. Further disclosed are methods by which a patient is provided both with unlabeled antibodies and with antibodies labeled with a radioisotope. Claims of the invention include tumor responses which can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy. Further therapies in the treatment of non-Hodgkin's disease are included. | | Abstract: | Methods for the treatment of lymphoma by administration of a B cell-specific antibody are described. The invention encompasses providing to a patient both unlabeled antibodies and antibodies labeled with a radioisotope. A principal advantage of the method is that tumor responses can be obtained in a radiometric dose range that does not require hematopoietic stem cell replacement as an adjunct therapy. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6565827 | | Application Number: | US2001000924360 | | Date Filed: | 07/08/2001 | | Date Published: | 20/05/2003 | | Assignee: | Coulter Pharmaceutical, Inc., South San Francisco, CA, USA
The Regents of the University of Michigan, Ann Arbor, MI, USA
Coulter Pharmaceutical, Inc., South San Francisco, CA, USA
The Regents of the University of Michigan, Ann Arbor, MI, USA |
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