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| Title: | Protein-induced tissue morphogenesis |
| Inventors: | Cohen, Charles M.; Medway, MA, USA Kuberasampath, Thangavel; Medway, MA, USA Pang, Roy H. L.; Medway, MA, USA Oppermann, Hermann; Medway, MA, USA Rueger, David C.; West Roxbury, MA, USA |
| Summary: | Described herein is a method of morphogen-induced modulation of the inflammatory response. The invention relates to methods, compositions and devices for inducing tissue-specific regeneration in a mammal, or for stimulating the proliferation of mammalian progenitor cells. Further disclosed are ways in which osteogenic protein 1 (OP-1) is utilized as a tissue morphogen, that is, as a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Several embodiments of the invention are provided, including one in which naturally-occurring or biosynthetic proteins are used in sharing a defined structural and functional relationship with OP-1 and also as tissue morphogens. Also provided are the means by which OP-1 or a related protein may be used alone or when adsorbed on a support matrix which provides an anchoring substratum for the proliferation or differentiation of progenitor cells during tissue-specific morphogenesis. The stimulation of mammalian progenitor cells ex vivo is further included, such that the stimulated cells, under specific conditions, exhibit tissue-specific morphogenesis to produce replacement tissue at a nonskeletal tissue locus such as at a nonbony or noncartilaginous tissue locus. Specific polypeptides are disclosed, as are therapeutic applications in the treatment of tissue damage, autoimmune diseases, diabetes, asthma, and ischemia reperfusion injury. |
| Abstract: | The invention provides methods, compositions and devices for inducing tissue-specific regeneration in a mammal, or for stimulating proliferation of mammalian progenitor cells. The present methods, compositions and devices make use of osteogenic protein 1 (OP-1), which is appreciated herein as a tissue morphogen, i.e., a substance competent to induce tissue-specific morphogenesis of mammalian body tissues in addition to bone and/or cartilage. Alternatively, the present methods, compositions and devices make use of other naturally-occurring or biosynthetic proteins sharing a defined structural and functional relationship with OP-1 and thus appreciated herein also to function as tissue morphogens. Optionally, OP-1 or a related protein can be used alone or when adsorbed on a support matrix which provides an anchoring substratum for proliferation and/or differentiation of progenitor cells during tissue-specific morphogenesis. In another embodiment, OP-1 or a related protein is used to stimulate mammalian progenitor cells ex vivo, such that the stimulated cells, when disposed in vivo in a mammal, undergo tissue-specific morphogenesis to produce replacement tissue at a nonskeletal tissue locus in need thereof (i.e., at a nonbony or noncartilaginous tissue locus in need thereof). |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6565843 |
| Application Number: | US1995000404113 |
| Date Filed: | 14/03/1995 |
| Date Published: | 20/05/2003 |
| Assignee: | Curis, Inc., Cambridge, MA, USA |