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Stem Cell Related Patent Number US6569654

Title:Electroactive materials for stimulation of biological activity of stem cells
Inventors:Shastri, Venkatram; Lower Gwynedd, PA, USA
Martin, Ivan; Oberwil, Switzerland Langer, Robert; Newton, MA, USA
Rahman, Nahid; Boston, MA, USA
Summary:Described herein is a method of stimulation of biological activity within a cell via the attachment or association of the cells to or with a surface comprising an electroactive material to which an electromagnetic field is applied at the desired area. The invention relates to the stimulation of biological activities within stem cells by application of an electromagnetic field to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. Claims if the invention describe stimulation of biological activities within cells which include, but are not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. Further disclosed are means by which the electroactive materials are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or three-dimensional substrates comprising a matrix having at least one surface of an electroactive material. Multiple embodiments of the invention are provided.
Abstract:Compositions, methods and systems are provided for the stimulation of biological activities within stem cells by applying electromagnetic stimulation to an electroactive material, wherein the electromagnetic stimulation is coupled to the electromagnetic material. In general the present invention involves attaching or associating the desired cells to or with a surface comprising an electroactive material, and applying electromagnetic radiation directly to the desired area. In preferred embodiments, the stimulation of biological activities within cells results from inducing one or more activities including, but not limited to, gene expression, cell growth, cell differentiation, signal transduction, membrane permeability, cell division, contraction, and cell signaling. In exemplary embodiments, the electroactive materials used in the present invention are either two-dimensional substrates such as thin films having at least one surface of an electroactive material, or in alternative embodiments, the electroactive materials are three-dimensional substrates comprising a matrix having at least one surface of an electroactive material.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6569654
Application Number:US2001000753407
Date Filed:02/01/2001
Date Published:27/05/2003
Assignee:Massachusetts Institute of Technology, Cambridge, MA, USA


 
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