Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6576812

Title:Compound screening assays using a transgenic mouse model of human skin diseases
Inventors:Longley, B. Jack; Hamden, CT, USA
Summary:This invention provides methods of identifying a composition, a compound or a procedure which can either produce a skin response in a subject, or reduce and treat a skin response in a subject. Further provided is a method of identifying a composition, a compound, or a procedure which can reduce radiation damage to the skin of a subject, and a pharmaceutical composition for treating human skin diseases. The model is the skin of a transgenic mouse which has been hyperpigmented and which has stably integrated into its genome a nucleic acid comprised of a human cytokeratin 14 promoter linked to a nucleic acid which encodes the epidermal stem cell factor, and which expresses the epidermal stem cell factor in the basal layers of its interadnexal epidermis and follicular epithelium. Also disclosed are methods concerning the administration to the transgenic mouse of a compound effective to treat the skin response.
Abstract:The present invention provides a method of identifying a composition, a compound or a procedure which can produce a skin response in a subject, and a method of identifying a composition, a compound, or a procedure which can reduce or treat skin response in a subject. The present invention further provides a method of identifying a composition, a compound, or a procedure which can reduce radiation damage to the skin of a subject, and a pharmaceutical composition for treating human skin diseases.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6576812
Application Number:US1999000306143
Date Filed:06/05/1999
Date Published:10/06/2003
Assignee:The Trustees of Columbia University in the City of New York, New York, NY, USA


 
Copyright © 2007 The Institute for Cellular Medicine  8/10/2020