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Stem Cell Related Patent Number US6586192
| Title: | Compositions and methods for use in affecting hematopoietic stem cell populations in mammals | | Inventors: | Peschle, Cesare; Rome, Italy
Ziegler, Benedikt L.; Tuebingen, Germany | | Summary: | Described herein are methods of obtaining and expanding a purified population of long-term repopulating hematopoietic stem cells (HSCs), and uses thereof. The invention relates to a process of obtaining such a cell population, methods of isolating the HSCs from human hematopoietic tissue, and methods of using a reagent to separate cells that express KDR on their surface (KDR+ cells) from cells that do not express KDR on their surface. Therapeutic applications in the treatment of hematopoietic disorders are included. | | Abstract: | The invention relates to a methods of obtaining and expanding a purified population of long-term repopulating hematopoietic stem cells. The invention also relates to the uses of a purified population of long-term repopulating hematopoietic stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6586192 | | Application Number: | US1999000322352 | | Date Filed: | 28/05/1999 | | Date Published: | 01/07/2003 | | Assignee: | Thomas Jefferson University, Philadelphia, PA, USA
Instituto Superiore di Sanita, Rome, Italy |
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