Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6589728

Title:Methods for isolation and activation of, and control of differentiation from, stem and progenitor cells
Inventors:Csete, Marie; South Pasadena, CA, USA
Doyle, John; South Pasadena, CA, USA
Wold, Barbara; San Marino, CA, USA
Summary:This invention describes methods of culturing neural crest stem cells in low ambient oxygen conditions, and methods for the screening of a compound which promotes the survival of stem or progenitor cells. The invention relates to a process of isolation, maintenance and enrichment for stem or progenitor cells derived from diverse organ or tissue sources. Further disclosed are methods for the controlled use of subatmospheric oxygen culture, and methods by which the precise oxygen levels must be determined empirically or by reference to physiological levels within intact functioning organ or tissue. Therapeutic applications in the treatment of neurodegenerative disorders are included.
Abstract:The present invention provides a method of isolating, maintaining, and/or enriching for stem or progenitor cells derived from diverse organ or tissue sources. The invention specifically teaches that these can be accomplished by the controlled use of subatmospheric oxygen culture, and that the precise oxygen level or levels must be determined empirically and/or by reference to physiologic levels within intact functioning organ or tissue.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6589728
Application Number:US2001000773824
Date Filed:31/01/2001
Date Published:08/07/2003
Assignee:California Institute Of Technology, Pasadena, CA, USA


 
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