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Stem Cell Related Patent Number US6596690
| Title: | Vasostatin as marrow protectant | | Inventors: | Tosato, Giovanna; Bethesda, MD, USA | | Summary: | Described herein are methods of inhibiting endothelial cell growth and angiogenesis via the use of calreticulin. The invention relates to specific fragments of vasostatin, and to a process of stimulating the proliferation or survival of a hematopoietic cell exposed either to a chemotherapeutic agent or to irradiation. Further disclosed is a method of stimulating the proliferation or survival of hematopoietic cells with a fragment of vasostatin in the presence of a growth factor. Various embodiments of the invention are provided, as are therapeutic applications in the suppression of tumor growth, and in the protection of bone marrow cells in a subject treated with a chemotherapeutic agent or suffering from radiation toxicity. | | Abstract: | Specific fragments of vasostatin are disclosed. Also disclosed is a method of stimulating the proliferation or survival of a hematopoietic cell exposed to a chemotherapeutic agent or irradiation using these fragments. A method of stimulating the proliferation or survival of a hematopoietic cell is also disclosed. In one embodiment, the method is disclosed for stimulating the growth or survival of a hematopoietic stem cell with a fragment of vasostatin, in the presence of a growth factor. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6596690 | | Application Number: | US2001000828000 | | Date Filed: | 06/04/2001 | | Date Published: | 22/07/2003 | | Assignee: | The USA as represented by the Department of Health and Human Services, Washington, DC, USA |
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