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| Title: | Secreted frizzled related protein, sFRP, fragments and methods of use thereof |
| Inventors: | Rubin, Jeffrey S.; Rockville, MD, USA Cumberledge, SUSA n; Amherst, MA, USA Reichsman, Frieda; Amherst, MA, USA Uren, Aykut; Baltimore, MD, USA |
| Summary: | Described herein are methods and uses of a new secreted frizzled related polypeptide (sFRP) and its fragments. Central to the invention is the discovery that sFRPs and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Claims of this invention include fragments of sFRPs that do not contain the CRD domain and which are shown to bind to Wnt proteins and modulate Wnt biological activity. Further disclosed are sFRP fragments and variants thereof, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and their variants. Therapeutic applications are included, such as in the screening of modulators of Wnt biological activity for treating disorders associated with increased Wnt biological activity, and for the suppression of tumor growth. |
| Abstract: | The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6600018 |
| Application Number: | US2000000546043 |
| Date Filed: | 10/04/2000 |
| Date Published: | 29/07/2003 |
| Assignee: | The USA as represented by the Department of Health and Human Services, Washington, DC, USA |