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Stem Cell Related Patent Number US6605275

Title:Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Inventors:Boyse, Edward A.; Tucson, AZ, USA
Summary:Described herein are methods of isolation and preservation of stem and progenitor cells derived from neonatal or fetal blood and which are cryopreserved. The invention relates to a specific therapeutic method of treating a human patient in need of hematopoietic reconstitution, in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. Further disclosed are methods by which the fetal or neonatal hematopoietic stem and progenitor cells, which contain a heterologous gene sequence, may be used for hematopoietic reconstitution in gene therapy. Also provided are methods by which the neonatal or fetal blood cells that have been cryopreserved and thawed may be used for autologous reconstitution.
Abstract:The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for hematopoietic (or immune) reconstitution. Hematopoietic reconstitution with the cells of the invention can be valuable in the treatment or prevention of various diseases and disorders such as anemias, malignancies, autoimmune disorders, and various immune dysfunctions and deficiencies. In another embodiment, fetal or neonatal hematopoietic stem and progenitor cells which contain a heterologous gene sequence can be used for hematopoietic reconstitution in gene therapy. In a preferred embodiment of the invention, neonatal or fetal blood cells that have been cryopreserved and thawed can be used for autologous (self) reconstitution.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6605275
Application Number:US1995000443221
Date Filed:17/05/1995
Date Published:12/08/2003
Assignee:PharmaStem Therapeutics, Inc., Wayne, PA, USA


 
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