Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6605710

Title:Gene whose expression promotes differentiation of myeloid progenitor cells into neutrophils and/or monocytes/macrophages
Inventors:Schwartz, Richard C.; Haslett, MI, USA
Tian, Qiang; Kenmore, WA, USA
Summary:Described herein are isolated cDNA molecules encoding the human C/EBP Differential Display Product-1 that promotes differentiation of undifferentiated cells, myeloid progenitor cells or hematopoietic cells. The invention relates to a human gene sequence that encodes the CDDP-1 polypeptide, which is involved in cell differentiation, in particular differentiation of undifferentiated progenitor cells into neutrophils, monocytes/macrophages, mast cells, and erythroid cells. Further disclosed are assays for detecting CDDP-1 expression, vectors that express CDDP-1, methods for using CDDP-1 to induce or promote cell differentiation, and transgenic animals deficient in one or both CDDP-1 alleles. Therapeutic applications are included, such as in the treatment of cancer, particularly leukemia.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6605710
Application Number:US2001000758623
Date Filed:11/01/2001
Date Published:12/08/2003
Assignee:Board of Trustees of Michigan State University, East Lansing, MI, USA


 
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