Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6617158

Title:Method for stimulating the production of fetal hemoglobin producing erythroid cells
Inventors:Bohmer, Ralph M.; Brookline, MA, USA
Summary:Described herein is a process of treating beta-hemoglobinopathy, via the introduction into a subject of erythroid cells treated with cytokines which increase the number of fetal hemoglobin producing cells. The invention relates to methods for ameliorating ?-globin disorders in a mammal, involving both the in vivo and ex vivo treatment of early erythroid progenitor cells that lead to an increase in the relative amounts of cells subsequently expressing and accumulating HbF. Further disclosed are methods by which the cell treatment is to be followed by transplantation of the modified cells. Central to the invention is the discovery that treatments may be performed very early in the erythroid maturation process, without disturbance of the subsequent proliferation and maturation of the erythroid precursor. Also provided is a procedure for the monitoring of ?-globinopathies and the response of a patient to treatment, in which the erythropoiesis of a patient is studied in vivo or in vitro by generating profiles of correlated contents of different types of hemoglobin present in nucleated red cells.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US6617158
Application Number:US2000000637539
Date Filed:11/08/2000
Date Published:09/09/2003
Assignee:New England Medical Center, Boston, MA, USA


 
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