Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6623934

Title:Bone morphogenetic protein-16 (BMP-16)antibodies
Inventors:Celeste, Anthony J.; Hudson, MA, USA
Murray, Beth L.; Arlington, MA, USA
Summary:Described herein is a novel isolated bone morphogenetic protein-16 (BMP-16), methods and uses thereof. The invention relates to an antibody that binds to purified BMP-16 polypeptides, and processes of production. Further disclosed are DNA molecules encoding the BMP-16 proteins. Therapeutic applications are included, such as in the treatment of bone, cartilage, and other connective tissue defects and disorders, in tissue repair for wound healing, in the treatment of disorders and defects of tissues such as epidermis, nerve, and muscle including cardiac muscle and other tissues and wounds, as well as in the treatment of organs such as lung, hepatic, cardiac, pancreatic and renal tissue. Also described are uses of the proteins in the induction of growth and the differentiation of undifferentiated embryonic and stem cells.
Abstract:Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6623934
Application Number:US2001000994177
Date Filed:26/11/2001
Date Published:23/09/2003
Assignee:Genetics Institute, LLC, Cambridge, MA, USA


 
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