Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6623942

Title:Macrophage inflammatory protein-4 (MIP-4) polynucleotides
Inventors:Ruben, Steven M.; Olney, MD, USA
Li, Haodong; Gaithersburg, MD, USA
Summary:Described herein are methods of purifying target proteins from inclusion bodies via treatment with low concentrations of a chaotropic agent to solubilize the protein for recovery. The invention relates to therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide, previously termed MIP-3, and chemokine ?8(CK?8 or ckb-8). Further disclosed is a human monocyte-colony inhibitory factor (M-CIF) polypeptide, previously termed MIP1-?, as well as chemokine ?1(CK?1 or ckb-1), a macrophage inhibitory protein-4 (MIP-4), and MPIF-1, M-CIF and/ MIP-4 polypeptides themselves. Also provided are vectors, host cells and recombinant methods for their production. Nucleotide sequences of the nucleic acid molecules are provided.
Abstract:There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine .beta.8(CK.beta.8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-.gamma. and chemokine .beta.1(CK.beta.1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6623942
Application Number:US1999000334954
Date Filed:17/06/1999
Date Published:23/09/2003
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA


 
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