Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6627191

Title:Anti-transforming growth factor Beta (TGF-.beta.) treated stem cell composition and method
Inventors:Bartelmez, Stephen H.; Seattle, WA, USA
Sitnicka, Ewa; Lund, Sweden Ruscetti, Frank; New Market, MD, USA
Summary:This invention describes a novel transforming growth factor-? antibody treated stem cell composition, and rapid in vivo hematopoietic system repopulation. The invention relates to stem cell compositions comprising anti-TGF-? treated stem cells which are viable for at least 14 days in vitro or ex vivo without replication or differentiation. Further disclosed are methods for rapid and long term in vitro hematopoiesis and in vivo hematopoietic reconstitution using such anti-TGF-? treated stem cells. Methods, materials and uses are provided.
Abstract:The invention relates to stem cell compositions comprising anti-TGF-.beta. treated stem cells which are viable for at least 14 days in culture without replication or differentiation and methods for rapid and long term in vitro hematopoiesis and in vivo hematopoietic reconstitution using such anti-TGF-.beta. treated stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6627191
Application Number:US2000000490520
Date Filed:25/01/2000
Date Published:30/09/2003
Assignee:Seattle Biomedical Research Institute, Seattle, WA, USA


 
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