Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6627759

Title:Method of isolating stem cells
Inventors:Smith, Clayton A.; Tampa, FL, USA
Colvin, Michael; Chapel Hill, NC, USA
Storms, Robert W.; Durham, NC, USA
Ludeman, SUSA
n M.; Durham, NC, USA
Summary:Described herein are methods of detection and isolation of stem cells via a substrate of aldehyde dehydrogenase which is converted to a detectable product. Methods and compounds for isolating stem cells and to suitable reagents are disclosed, including a fluorescent aldehyde dehydrogenase substrate composed of an aminoacetaldehyde moiety bearing a fluorescent BODIPY label. Also provided is a kit comprising the BODIPY aminoacetaldehyde diethyl acetal compound. Therapeutic applications are included, such as in organ transplantation and gene therapy.
Abstract:The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to stem cell populations isolatable in accordance with the present method.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6627759
Application Number:US2001000701413
Date Filed:20/02/2001
Date Published:30/09/2003
Assignee:Duke University, Durham, NC, USA


 
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