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Stem Cell Related Patent Number US6630143
| Title: | Antibodies against flt3 ligand | | Inventors: | Lyman, Stewart D.; Seattle, WA, USA
Beckmann, Patricia M.; Poulsbo, WA, USA | | Summary: | Described herein are novel antibodies specifically binding to human flt-3 ligand, and methods of their use in immunoassays for measuring the concentration of flt3-L in plasma or serum. The invention relates to ligands for flt3 receptors which are capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells. Further disclosed are anti-flt3-L antibodies encoded by the cDNA insert of vector huflt3/flk-2L (#9-2) in E. coli DH10?a having ATCC Accession No. 69382, and enzyme-linked immunosorbent assays comprising such antibodies. Therapeutic applications are included, such as predicting the status of a disease such as Fanconi’s anemia or acquired aplastic anemia. | | Abstract: | Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to anti-flt3-L antibodies and enzyme-linked immunosorbent assays comprising such antibodies. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6630143 | | Application Number: | US1996000669692 | | Date Filed: | 24/06/1996 | | Date Published: | 07/10/2003 | | Assignee: | Immunex Corporation, Seattle, WA, USA |
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