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Stem Cell Related Patent Number US6632620
| Title: | Compositions for identification and isolation of stem cells | | Inventors: | Makarovskiy, Andrew N.; Mendon, MA, USA | | Summary: | Described herein are novel antibodies that selectively bind to ectodermally- or endodermally-derived stem cell. The invention relates to such monoclonal antibodies and methods of their use in the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Further disclosed are methods for isolating such stem cells from a heterogeneous cell population by contacting the population with antibodies which selectively bind to stem cells, wherein the heterogenous cell population consists of an epithelial stem cell, a skin stem cell, a neural stem cell, and an ocular stem cell, wherein the antibody comprises mAb 7.22.3 (SCS7), and has all identifying characteristics of a monoclonal antibody produced by a hybridoma cell line deposited with the American Type Culture Collection as Accession No. PTA-4655. Therapeutic applications are included, such as in the treatment of carcinomas, in the identification and isolation of tissue-specific stem cells, and in the diagnosis of a neoplasm. | | Abstract: | The invention provides monoclonal antibodies that selectively bind to ectodermally- and endodermally-derived stem cells and methods for the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Also disclosed are methods for isolating such stem cells from a heterogeneous cell population by contacting the population with antibodies which selectively bind to stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6632620 | | Application Number: | US2000000603453 | | Date Filed: | 22/06/2000 | | Date Published: | 14/10/2003 | | Assignee: | Makarovskiy; Andrew N., Mendon, MA, USA |
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