Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6632620

Title:Compositions for identification and isolation of stem cells
Inventors:Makarovskiy, Andrew N.; Mendon, MA, USA
Summary:Described herein are novel antibodies that selectively bind to ectodermally- or endodermally-derived stem cell. The invention relates to such monoclonal antibodies and methods of their use in the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Further disclosed are methods for isolating such stem cells from a heterogeneous cell population by contacting the population with antibodies which selectively bind to stem cells, wherein the heterogenous cell population consists of an epithelial stem cell, a skin stem cell, a neural stem cell, and an ocular stem cell, wherein the antibody comprises mAb 7.22.3 (SCS7), and has all identifying characteristics of a monoclonal antibody produced by a hybridoma cell line deposited with the American Type Culture Collection as Accession No. PTA-4655. Therapeutic applications are included, such as in the treatment of carcinomas, in the identification and isolation of tissue-specific stem cells, and in the diagnosis of a neoplasm.
Abstract:The invention provides monoclonal antibodies that selectively bind to ectodermally- and endodermally-derived stem cells and methods for the diagnosis of a neoplasm in a subject by contacting a tissue sample from the subject with the antibodies. Also disclosed are methods for isolating such stem cells from a heterogeneous cell population by contacting the population with antibodies which selectively bind to stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6632620
Application Number:US2000000603453
Date Filed:22/06/2000
Date Published:14/10/2003
Assignee:Makarovskiy; Andrew N., Mendon, MA, USA


 
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