Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6638501

Title:Use of multipotent neural stem cell progeny to augment non-neural tissues
Inventors:Bjornson, Christopher R.; Calgary, Canada
Rietze, Rod L.; Calgary, Canada
Reynolds, Brent A.; Saltspring, Canada
Vescovi, Angelo L.; Milan, Italy
Summary:Described herein are methods of generating hematopoietic cells from multipotent neural stem cells (MNSC). The invention relates to a process of increasing the hematopoietic cells of a mammal by administering MNSC progeny at a site or sites outside of the mammalís central nervous system, where the MNSC progeny integrate with the hematopoietic tissue. The MNSC progeny are described as being allogeneic or autologous to the mammal, amenable to genetic modification, and have a universal lineage potential as well as the capacity for producing progeny which, in response to appropriate environmental signals, can differentiate into a variety of differentiated cell types, and not just neural lineages. Claims of the invention include methods by which the MNSCs may be proliferated ex vivo to provide an unlimited supply of stem cells and stem cell progeny which give rise to the differentiated cell types of various tissues. Therapeutic applications include treatment with transplanted MNSC progeny to augment host tissue.
Abstract:Multipotent neural stem cell (MNSC) progeny are transplanted into a recipient wherein they augment host tissue. The stem cells have a universal lineage potential and are capable of producing progeny that, in response to appropriate environmental signals, can differentiate into a variety of differentiated cell types, and not just neural lineages. MNSCs can be proliferated ex vivo to provide an unlimited supply of stem cells and stem cell progeny which give rise to the differentiated cell types of various tissues. The stem cells are readily amenable to genetic modification, if desired. They also have the advantage that they can be obtained from autologous adult human tissue and thus overcome prior art problems of transplant rejections.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6638501
Application Number:US1998000100296
Date Filed:19/06/1998
Date Published:28/10/2003
Assignee:NeuroSpheres Holdings Ltd., Alberta, Canada


 
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