Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6652860

Title:Peptide, apoEp 1.B, compositions and uses thereof
Inventors:Singh, Bhagirath; London, Canada
Rider, Beverley; Palo Alto, CA, USA
Summary:Described herein is a peptide derived from apolipoprotein E, termed apoEp1.B, which includes amino acids 239-252 of the apolipoprotein E. Claims of the invention describe the apoEp1.B peptide as a potent immune modulator that acts on a variety of immune cells, acting also as a dual modulator, capable both of inducing and suppressing an immune response. Methods are disclosed by which apoEp1.B has been shown to induce differentiation of stem cells into dendritic cells, to induce tumor cell differentiation and activation, to inhibit inflammation and to inhibit autoimmune disease. Therapeutic applications include the treatment and prevention of inflammatory diseases, and immune modulation via the administration of an effective amount of an apoEp1.B peptide or a nucleic acid encoding an apoEp1.B peptide to a cell or animal in need thereof.
Abstract:A peptide derived from apolipoprotein E termed apoEp1.B which includes amino acids 239-252 of the apolipoprotein E is described. The apoEp1.B peptide is a potent immune modulator that acts on a variety of immune cells. Interestingly, apoEp1.B is a dual modulator, capable of both inducing and suppressing an immune response. In particular, apoEp1.B has been shown to induce differentiation of stem cells into dendritic cells, to induce tumor cell differentiation and activation, to inhibit inflammation and to inhibit autoimmune disease.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6652860
Application Number:US2000000581153
Date Filed:07/08/2000
Date Published:25/11/2003
Assignee:University of Western Ontario, London, Canada


 
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