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Stem Cell Related Patent Number US6660256
| Title: | Porcine mpl ligand | | Inventors: | Eaton, Dan L.; San Rafael, CA, USA
de Sauvage, Frederic J.; Foster City, CA, USA | | Summary: | Described herein is a thrombopoietin polypeptide and isolated substantially homogeneous porcine ligand for an mpl cytokine receptor. The invention relates to an isolated DNA encoding mpl ligand and recombinant methods of preparing mpl ligand, which are shown to influence the replication, differentiation and maturation of blood cells, especially megakaryocyte progenitor cells. Therapeutic applications for the treatment of thrombocytopenia are included. | | Abstract: | Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenitor cells. Accordingly, these compounds are used for treatment of thrombocytopenia. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6660256 | | Application Number: | US1994000348657 | | Date Filed: | 02/12/1994 | | Date Published: | 09/12/2003 | | Assignee: | Genetech, Inc., South San Francisco, CA, USA |
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