Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6660256

Title:Porcine mpl ligand
Inventors:Eaton, Dan L.; San Rafael, CA, USA
de Sauvage, Frederic J.; Foster City, CA, USA
Summary:Described herein is a thrombopoietin polypeptide and isolated substantially homogeneous porcine ligand for an mpl cytokine receptor. The invention relates to an isolated DNA encoding mpl ligand and recombinant methods of preparing mpl ligand, which are shown to influence the replication, differentiation and maturation of blood cells, especially megakaryocyte progenitor cells. Therapeutic applications for the treatment of thrombocytopenia are included.
Abstract:Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication, differentiation or maturation of blood cells, especially megakaryocyte progenitor cells. Accordingly, these compounds are used for treatment of thrombocytopenia.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6660256
Application Number:US1994000348657
Date Filed:02/12/1994
Date Published:09/12/2003
Assignee:Genetech, Inc., South San Francisco, CA, USA


 
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