|
|
|
Stem Cell Related Patent Number US6664107
| Title: | CD45 disrupted nucleic acid | | Inventors: | Mak, Tak Wah; Toronto, Canada
Kishihara, Kenji; Fukuoka, Japan | | Summary: | This invention introduces a nonhuman mammal and its progeny with suppressed expression of the gene encoding CD45 on B cells. Specifically, the authors describe a mouse lacking expression of a particular CD45 isoform in certain cells of the immune system, such that the mouse may optionally contain a transgene encoding the CD45RO isoform. Further disclosed is a DNA sequence comprising at least exons 6-8 of a mouse CD45 DNA construct into which a marker gene sequence has been substituted for at least exon 6 and intron 6. Specific DNA sequences are delineated, as are applications in the screening of drugs for their immunomodulatory effects. | | Abstract: | A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6664107 | | Application Number: | US1994000191225 | | Date Filed: | 02/02/1994 | | Date Published: | 16/12/2003 | | Assignee: | Ontario Cancer Institute, University Health Network, Toronto, Canada |
|
|
