Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6664107

Title:CD45 disrupted nucleic acid
Inventors:Mak, Tak Wah; Toronto, Canada
Kishihara, Kenji; Fukuoka, Japan
Summary:This invention introduces a nonhuman mammal and its progeny with suppressed expression of the gene encoding CD45 on B cells. Specifically, the authors describe a mouse lacking expression of a particular CD45 isoform in certain cells of the immune system, such that the mouse may optionally contain a transgene encoding the CD45RO isoform. Further disclosed is a DNA sequence comprising at least exons 6-8 of a mouse CD45 DNA construct into which a marker gene sequence has been substituted for at least exon 6 and intron 6. Specific DNA sequences are delineated, as are applications in the screening of drugs for their immunomodulatory effects.
Abstract:A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6664107
Application Number:US1994000191225
Date Filed:02/02/1994
Date Published:16/12/2003
Assignee:Ontario Cancer Institute, University Health Network, Toronto, Canada


 
Copyright © 2007 The Institute for Cellular Medicine  8/5/2020