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Stem Cell Related Patent Number US6667024
| Title: | Alpha or beta emitters attached to fragments in radioimmunotherapy | | Inventors: | Goldenberg, David M.; Mendham, NJ, USA
Behr, Thomas M.; Goettingen, Germany | | Summary: | Described herein is a kit for radioimmunotherapy, comprising radioimmunoconjugates, methods and uses thereof. The invention relates to radioimmunoconjugates comprised of an alpha- or beta-emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. Therapeutic applications include targeted radioimmunotherapy such as in the treatment of tumors, as well as the administration of one or more clearing agents to a patient in conjunction with the radioimmunoconjugates along with the subsequent grafting of bone-marrow or autologous stem-cells. | | Abstract: | The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present invention comprise an alpha- or beta-emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. The methods of treating a patient can include administering one or more clearing agents to the patient in conjunction with the radioimmunoconjugate of the present invention, as well as subsequently grafting bone-marrow or autologous stem-cells to the patient. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6667024 | | Application Number: | US2000000588565 | | Date Filed: | 07/06/2000 | | Date Published: | 23/12/2003 | | Assignee: | Center for Molecular Medicine and Immunology, Belleville, NJ, USA |
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