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| Title: | Stem cell growth factor-like polypeptide |
| Inventors: | Drmanac, Radoje T.; Palo Alto, CA, USA Labat, Ivan; Mountain View, CA, USA Tang, Y. Tom; San Jose, CA, USA Chao, Cheng-Chi; Cupertino, CA, USA Mize, Nancy K.; Mountain View, CA, USA Childs, John; Sunnyvale, CA, USA |
| Summary: | Described herein is an isolated polypeptide with stem cell growth factor-like activity. The invention relates to novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein comprising nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain and testis. Further disclosed are vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. Therapeutic applications are included, such as in the treatment of leukemia, hemophilia, degenerative diseases such as Alzheimer's disease, and in the generation of new tissues and organs |
| Abstract: | The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen (Hyseq clone identification number 6118092), ovary (Hyseq clone identification number 8375786), adult brain (Hyseq clone identification numbers 701734, 15327638, 15741682, 15954941, 15955015), lung tumor (Hyseq clone identification number 11047146 and 10280328), spinal cord (Hyseq clone identification number 10102150), cervix (Hyseq clone identification numbers 10022437 and 14029194), ovary (Hyseq clone identification number 8319153), endothelial cells (Hyseq clone identification number 13815744), umbilical cord (Hyseq clone identification number 18568149), lymphocyte (Hyseq clone identification number 10257378), lung fibroblast (Hyseq clone identification number 17116257), fetal brain (Hyseq clone identification number 15266959), and testis. Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6667391 |
| Application Number: | US2001000764325 |
| Date Filed: | 16/01/2001 |
| Date Published: | 23/12/2003 |
| Assignee: | None |