Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6670123

Title:Method for detecting hematopoietic stem cells
Inventors:Belyavsky, Alexander; New York, NY, USA
Shmelkov, Sergey; Union City, NJ, USA
Visser, Jan; New York, NY, USA
Summary:This invention introduces a novel nucleic acid and its uses as a genetic marker for identifying or detecting the presence of hematopoietic stem cells in a heterogenous cell suspension. Claims of the invention include an isolated nucleic acid encoding KIAA0918, an isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a purified KIAA0918 protein, a purified protein encoded by the same, a method of making the KIAA0918 protein, an antibody specific for KIAA0918 and the corresponding method for producing the antibody, a vector comprising a nucleic acid encoding KIAA0918, and a host cell transformed with a vector comprising a nucleic acid encoding KIAA0918. Also provided are methods for the assessment of gene expression in a tissue sample. Therapeutic applications are included, such as in the treatment of non-Hodgkin's lymphomas.
Abstract:The present invention provides an isolated nucleic acid encoding KIAA0918, an isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a purified KIAA0918 protein, a purified protein encoded by a nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a method of making KIAA0918 protein, an antibody specific for KIAA0918, a method for producing an antibody specific for KIAA0918 protein, a vector comprising a nucleic acid encoding KIAA0918, and a host cell transformed with a vector comprising a nucleic acid encoding KIAA0918. Also provided are methods for detecting the presence of and isolating hematopoietic stem cells in a heterogeneous cell suspension and for assessing gene expression in a tissue sample.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6670123
Application Number:US2000000706594
Date Filed:03/11/2000
Date Published:30/12/2003
Assignee:New York Blood Center, Inc., New York, NY, USA


 
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