|
|
|
Stem Cell Related Patent Number US6670123
| Title: | Method for detecting hematopoietic stem cells | | Inventors: | Belyavsky, Alexander; New York, NY, USA
Shmelkov, Sergey; Union City, NJ, USA
Visser, Jan; New York, NY, USA | | Summary: | This invention introduces a novel nucleic acid and its uses as a genetic marker for identifying or detecting the presence of hematopoietic stem cells in a heterogenous cell suspension. Claims of the invention include an isolated nucleic acid encoding KIAA0918, an isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a purified KIAA0918 protein, a purified protein encoded by the same, a method of making the KIAA0918 protein, an antibody specific for KIAA0918 and the corresponding method for producing the antibody, a vector comprising a nucleic acid encoding KIAA0918, and a host cell transformed with a vector comprising a nucleic acid encoding KIAA0918. Also provided are methods for the assessment of gene expression in a tissue sample. Therapeutic applications are included, such as in the treatment of non-Hodgkin's lymphomas. | | Abstract: | The present invention provides an isolated nucleic acid encoding KIAA0918, an isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a purified KIAA0918 protein, a purified protein encoded by a nucleic acid that hybridizes under high stringency conditions to a nucleic acid that is complementary to a nucleic acid encoding KIAA0918, a method of making KIAA0918 protein, an antibody specific for KIAA0918, a method for producing an antibody specific for KIAA0918 protein, a vector comprising a nucleic acid encoding KIAA0918, and a host cell transformed with a vector comprising a nucleic acid encoding KIAA0918. Also provided are methods for detecting the presence of and isolating hematopoietic stem cells in a heterogeneous cell suspension and for assessing gene expression in a tissue sample. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6670123 | | Application Number: | US2000000706594 | | Date Filed: | 03/11/2000 | | Date Published: | 30/12/2003 | | Assignee: | New York Blood Center, Inc., New York, NY, USA |
|
|
