Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6677311

Title:Inducible HSV-TK in transformed cell populations
Inventors:Evans, Ronald M.; La Jolla, CA, USA
Borrelli, Emiliana; Strasbourg Cedex, France
Heyman, Richard Alan; Encinitas, CA, USA
Summary:This invention describes a method of selectively inhibiting the growth of a tissue-type or cell line, via the administration of a latent toxin that triggers generation of the cell toxin by enzymatic conversion of the latent toxin. The invention relates to a new method of selection for inducibly and genetically ablating specific cell lineages in transgenic cell populations and in transgenic animals. The new method is described as permitting the production of stable transgenic perigees, useful at various stages of development of a transgenic cell population, and which allows both the timing and the degree of cellular ablation to be controlled. Applications are included in the study of cell lineages and organogeneis, especially in immunological disorders.
Abstract:The present invention discloses a new selective method for inducibly and genetically ablating specific cell lineages in transgenic cell populations, e.g., in transgenic animals. The new method, which permits the production of stable transgenic perigees, and thus can be used at various stages of development of a transgenic cell population, allows both the timing and the degree of cellular ablation to be controlled. As a result the method can be used for a variety of therapeutic applications, as well as to study cell lineages and organogenesis, plus the capacity that residual stem cells have for regeneration.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6677311
Application Number:US1995000464271
Date Filed:05/06/1995
Date Published:13/01/2004
Assignee:The Salk Institute for Biological Studies, La Jolla, CA, USA


 
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