Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6677434

Title:Soluble human flk-2 protein
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:Described herein is a novel protein tyrosine kinase expressed in primitive hematopoietic cells (HC) and not expressed in mature HC, and ligands for the protein. The invention relates to isolated mammalian nucleic acid molecules encoding such receptor protein tyrosine kinases, and the receptors encoded by such nucleic acid molecules. The isolated protein is described as comprising the extracellular domain of human flk-2 having the sequence shown in SEQ ID NO: 4, wherein the protein lacks the flk-2 intracellular catalytic domain. Further amino acid sequences are provided.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6677434
Application Number:US2001000872136
Date Filed:01/06/2001
Date Published:13/01/2004
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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