Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6679898

Title:Devices and methods for harvesting limbal stem cells
Inventors:Chuck, Roy S.; Irvine, CA, USA
Summary:This invention describes a process for harvesting from a mammalian donor a graft from the eye containing limbal stem cells and corneal tissue. The invention relates to a system, apparatus and method for harvesting from the eye of a mammilian cadaver a disc-shaped graft or lenticle consisting of corneal tissue and a quantity of scleral or pericorneal tissue wherein limbal stem cells are located. Further disclosed are means by which the graft or lenticle is then transplanted onto the eye of a human or veterinary patient to treat a disorder caused by the absence or deficiency of limbal stem cells in the patient's eye. Methods are provided for the use of an eye-contacting ring and a cutter guide apparatus along with the cutter apparatus itself in the harvesting of the cells and tissue.
Abstract:A system, apparatus and method for harvesting from the eye of a mammilian (e.g., cadaveric) donor a disc-shaped graft or lenticle consisting of corneal tissue and a quantity of scleral or pericorneal tissue wherein limbal stem cells are located. This graft or lenticle is then transplanted onto the eye of a human or veterinary patient to treat a disorder caused by the absence or deficiency of limbal stem cells in the patient's eye. The system of the present invention comprises a) an eye-contacting ring and cutter guide apparatus and b) a cutter apparatus. The eye-contacting ring and cutter guide apparatus is initially placed in contact with the donor eye such that a portion of the cornea and adjacent scleral or pericorneal tissue containing limbal stem cells protrudes upwardly through the center of the ring. The cutter is then engaged with guide member(s) formed on the ring and the cutter is advanced, severing the protruding cornea and stem-cell-containing pericorneal tissue. In this manner the desired lenticle is obtained for subsequent transplantation.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6679898
Application Number:US2001000965124
Date Filed:27/09/2001
Date Published:20/01/2004
Assignee:The Regents of the University of California, Oakland, CA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/18/2021