Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6703017

Title:Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
Inventors:Peck, Ammon B.; Gainesville, FL, USA
Cornelius, Janet; Gainesville, FL, USA
Ramiya, Vijayakumar K.; Gainesville, FL, USA
Summary:Described herein is a method of treating pancreatic disease. The invention relates to processes by which islet-producing stem cells (ISPCs) and their derivatives are grown, such that pancreatic tissue is grown under conditions that eliminate differentiated cells. Claims of the invention include the new possibility of growing in vitro functional IPSCs islet progenitor cells (IPCs) and IPC-derived islets (IdIs) in cultures. Further disclosed are methods of implanting the IPSCs, IPCs and/or IdIs for into a mammal for in vivo therapy of diabetes, as well as a process of using the implanted cells for growing a pancreas-like structure in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic endocrine tissue. Therapeutic applications in the treatment of diabetes are included.
Abstract:The subject invention concerns new methods which make it possible, for the first time, to grow functional islet-producing stem cells (IPSCs), islet progenitor cells (IPCs) and IPC-derived islets (IdIs) in in vitro cultures. The subject invention also concerns the use of the in vitro grown IPSCs, IPCs and/or IdIs for implantation into a mammal for in vivo therapy of diabetes. The subject invention further concerns a process of using the implanted cells for growing a pancreas-like structure in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic endocrine tissue. The ability to grow these cells in vitro and pancreas-like structures in vivo opens up important new avenues for research and therapy relating to diabetes.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6703017
Application Number:US1999000406253
Date Filed:27/09/1999
Date Published:09/03/2004
Assignee:Ixion Biotechnology, Inc., Alachua, FL, USA University of Florida, Gainesville, FL, USA


 
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