Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6703209

Title:Porcine totipotent cells and method for long-term culture
Inventors:Baetscher, Manfred; Portland, OR, USA
Brem, Gottfried; Hilgetshausen-Tandem, Germany
Summary:This invention describes the culturing of a porcine pluripotent cell factor (PSCF) in the presence of STO8 feeder cells expressing a PSCF. The PSCF is also termed herein “porcine steel factor, which is described preferably as being a membrane-bound PSCF on transfected murine STO feeder cells. Applications are provided in the establishment of pluripotent or totipotent porcine cell lines, especially for the culture of porcine primordial germ cells (PGCs).
Abstract:This invention provides a method of using a porcine stem cell factor (PSCF), which may also be termed porcine steel factor, which is preferably membrane-bound PSCF on transfected murine STO feeder cells, for establishing pluripotent or totipotent porcine cell lines, especially for the culture of porcine primordial germ cells (PGCs).
US Patent Website:Click Here for Full Text of Patent
Title Number:US6703209
Application Number:US1998000133352
Date Filed:13/08/1998
Date Published:09/03/2004
Assignee:BioTransplant, Inc., Charlestown, MA, USA


 
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