Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6703238

Title:Methods for expanding antigen-specific T cells
Inventors:Bachovchin, William; Melrose, MA, USA
Wallner, Barbara; Weston, MA, USA
Summary:Described herein are methods for stimulating hematopoietic cells in vitro via a process of culturing the cells in the presence of an inhibitor and in the absence of exogenous cytokines. The invention relates to methods for expanding antigen-specific T cells in vitro, and methods of contacting hematopoietic precursor or progenitor cells with a heteroconjugate containing an inhibitor of dipeptidyl peptidase (DPIV) attached to an antigenic peptide, optionally with a culture step to expand T cells with a DPIV inhibitor. Further provided are the means by which the culturing may be performed in the absence of exogenously provided cytokines. Therapeutic applications are included, such as in the treatment of immunosuppressed patients after chemotherapy or radiation therapy for cancer.
Abstract:Methods for expanding antigen-specific T cells in vitro are provided. The methods involve contacting hematopoietic precursor or progenitor cells with a heteroconjugate containing an inhibitor of dipeptidyl peptidase (DPIV) attached to an antigenic peptide, optionally with a culture step to expand T cells with a DPIV inhibitor. The culture may be performed in the absence of exogenously provided cytokines.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6703238
Application Number:US2001000812528
Date Filed:20/03/2001
Date Published:09/03/2004
Assignee:Point Therapeutics, Inc., Boston, MA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/22/2021