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Stem Cell Related Patent Number US6703238
| Title: | Methods for expanding antigen-specific T cells | | Inventors: | Bachovchin, William; Melrose, MA, USA
Wallner, Barbara; Weston, MA, USA | | Summary: | Described herein are methods for stimulating hematopoietic cells in vitro via a process of culturing the cells in the presence of an inhibitor and in the absence of exogenous cytokines. The invention relates to methods for expanding antigen-specific T cells in vitro, and methods of contacting hematopoietic precursor or progenitor cells with a heteroconjugate containing an inhibitor of dipeptidyl peptidase (DPIV) attached to an antigenic peptide, optionally with a culture step to expand T cells with a DPIV inhibitor. Further provided are the means by which the culturing may be performed in the absence of exogenously provided cytokines. Therapeutic applications are included, such as in the treatment of immunosuppressed patients after chemotherapy or radiation therapy for cancer. | | Abstract: | Methods for expanding antigen-specific T cells in vitro are provided. The methods involve contacting hematopoietic precursor or progenitor cells with a heteroconjugate containing an inhibitor of dipeptidyl peptidase (DPIV) attached to an antigenic peptide, optionally with a culture step to expand T cells with a DPIV inhibitor. The culture may be performed in the absence of exogenously provided cytokines. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6703238 | | Application Number: | US2001000812528 | | Date Filed: | 20/03/2001 | | Date Published: | 09/03/2004 | | Assignee: | Point Therapeutics, Inc., Boston, MA, USA |
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