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| Title: | Nicotine receptor agonists in stem cell and progenitor cell recruitment |
| Inventors: | Cooke, John; Palo Alto, CA, USA Johnson, Frances Lauri; Portola Valley, CA, USA Pathak, Anjali; Campbell, CA, USA Jang, James; San Bruno, CA, USA Tsao, Phillip; San Jose, CA, USA Heeschen, Christopher; Menlo Park, CA, USA |
| Summary: | Described herein are methods of mobilizing mammalian stem and progenitor cells using a nicotine receptor agonist. The invention relates to methods of recruitment of bone marrow-derived stem cells such as endothelial cell precursors and hematopoietic stem cells, via the administration of nicotine or another nicotine receptor agonist such as a nicotine salt, a nicotine metabolite or a derivative thereof. Therapeutic applications are included, such as in the treatment of neutropenia. |
| Abstract: | The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia). |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US6720340 |
| Application Number: | US2000000627643 |
| Date Filed: | 28/07/2000 |
| Date Published: | 13/04/2004 |
| Assignee: | The Board of Trustees of the Leland Stanford, Jr. Unversity, Palo Alto, CA, USA |