Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6720340

Title:Nicotine receptor agonists in stem cell and progenitor cell recruitment
Inventors:Cooke, John; Palo Alto, CA, USA
Johnson, Frances Lauri; Portola Valley, CA, USA
Pathak, Anjali; Campbell, CA, USA
Jang, James; San Bruno, CA, USA
Tsao, Phillip; San Jose, CA, USA
Heeschen, Christopher; Menlo Park, CA, USA
Summary:Described herein are methods of mobilizing mammalian stem and progenitor cells using a nicotine receptor agonist. The invention relates to methods of recruitment of bone marrow-derived stem cells such as endothelial cell precursors and hematopoietic stem cells, via the administration of nicotine or another nicotine receptor agonist such as a nicotine salt, a nicotine metabolite or a derivative thereof. Therapeutic applications are included, such as in the treatment of neutropenia.
Abstract:The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).
US Patent Website:Click Here for Full Text of Patent
Title Number:US6720340
Application Number:US2000000627643
Date Filed:28/07/2000
Date Published:13/04/2004
Assignee:The Board of Trustees of the Leland Stanford, Jr. Unversity, Palo Alto, CA, USA


 
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