Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6723534

Title:Purified and isolated PIWI family genes and gene products and therapeutic and screening methods using same
Inventors:Lin, Haifan; Durham, NC, USA
Summary:Described herein are piwi family nucleic acids, polypeptides, and antibodies. The invention relates to a biologically active family of isolated and purified proteins and nucleic acids, namely, the piwi family of proteins and cDNAs encoding the proteins. Further disclosed are recombinant host cells, recombinant nucleic acids, recombinant proteins, transgenic animals and isolated and purified antibodies to piwi family homologs. Claims of the invention include piwi family gene products which are described as having activity in the growth, proliferation and self-renewing division of stem cells, and in the proliferation of primordial germ cells. Therapeutic applications are included, such as in gene therapy for the treatment of cancer.
Abstract:A family of isolated and purified proteins and nucleic acids are disclosed. Particularly, piwi family proteins and cDNAs encoding the same are disclosed. Recombinant host cells, recombinant nucleic acids, recombinant proteins and transgenic animals are also disclosed, along with methods of producing each. Isolated and purified antibodies to piwi family homologs, and methods of producing the same, are also disclosed. piwi family gene products are characterized as having activity in the growth, proliferation and self-renewing division of stem cells, and proliferation of primordial germ cells. Thus, therapeutic, screening, culturing and transgenic methods involving these activities are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6723534
Application Number:US2001000873737
Date Filed:04/06/2001
Date Published:20/04/2004
Assignee:Duke University, Durham, NC, USA


 
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