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Stem Cell Related Patent Number US6734014
| Title: | Methods and compositions for transforming dendritic cells and activating T cells | | Inventors: | Hwu, Patrick; Rockville, MD, USA
Reeves, Mark; New York, NY, USA
Rosenberg, Steven A.; Potomac, MD, USA | | Summary: | Described herein is a novel method of making a mammalian dendritic cell via transduction with a selected nucleic acid. The invention relates to novel transformed dendritic cells produced by transducing hematopoietic stem cells with a nucleic acid and differentiating the cells into recombinant dendritic cells such that the resulting dendritic cells are antigen-presenting cells which activate T cells against MHC class I-antigen targets. Kits and assays are provided, based upon the activation of T cells by the recombinant dendritic cell. Pharmaceutical compositions and therapeutic applications are included, such as in activating T cells in the treatment of cancer, viral infections and parasitic infections. | | Abstract: | Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6734014 | | Application Number: | US1999000117764 | | Date Filed: | 07/01/1999 | | Date Published: | 11/05/2004 | | Assignee: | The USA as represented by the Department of Health and Human Services, Washington, DC, USA |
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