Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6734336

Title:Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring
Inventors:Scott, Richard W.; West Chester, PA, USA
Reaume, Andrew G.; Waterford, CT, USA
Dorfman, Karen; Waterford, CT, USA
Summary:This invention describes a novel gene-targeted mouse heterozygous for human Familial Alzheimer's Disease (FAD) mutation, and the generational offspring thereof, comprising a human mutation of FAD presenilin-1 (PS-1), a human transgene for FAD Swedish APP695, and a humanized Abeta (A?42) mutation, such that the A?42 protein level is elevated relative to the A?42 protein level in a wild-type mouse. Also included are therapeutic applications of such a non-human mammal in identifying compounds for the treatment of Alzheimer's disease.
Abstract:The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized A.beta. mutation, and generational offspring thereof and a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD PS-1 gene and a human Swedish APP695 mutation, and generational offspring thereof, as well as methods of identifying compounds useful in treating Alzheimer's disease, and to methods of treating Alzheimer's disease.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6734336
Application Number:US2000000621897
Date Filed:20/07/2000
Date Published:11/05/2004
Assignee:Cephalon, Inc., West Chester, PA, USA


 
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