Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6743772

Title:Use of parovirus capsid particles in the inhibition of cell proliferation and migration
Inventors:Broliden, Kristina; S-182 39 Danderyd, Sweden Westgren, Magnus; S-112 20 Stockholm, Sweden
Summary:Described herein is a process of inhibiting hematopoiesis of a hematopoietic cell. Central to the invention is the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have the P antigen, including cells of hematopoietic origin and endothelial cells. Disclosed herein are methods by which empty non-infectious recombinant B19 parvovirus capsids, B19 capsid proteins or fragments of B19 capsid proteins are used to manufacture medicaments that can be administered to a subject to inhibit hematopoietic progenitor cell growth prior to stem cell transplantation. Further described are therapeutic applications by which endothelial cell growth may be employed as an anti-tumorigenesis treatment or to prevent restenosis or fibrotic build up following prosthetic implantation, or to prevent disorders that involve the abnormal proliferation of cells that have the P antigen such as polycytemia vera.
Abstract:The invention described herein relates to the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have the P antigen, including but not limited to, cells of hematopoietic origin and endothelial cells. More specifically, parvovirus capsid particles or fragments of parvovirus capsid proteins are used to manufacture medicaments that can be administered to a subject to inhibit hematopoietic progenitor cell growth (e.g., prior to stem cell transplantation), endothelial cell growth, (e.g., as an anti-tumorigenesis treatment or to prevent restenosis or fibrotic build up following prosthetic implantation), or to prevent disorders that involve the abnormal proliferation of cells that have the P antigen (e.g., polycytemia vera).
US Patent Website:Click Here for Full Text of Patent
Title Number:US6743772
Application Number:US2002000200616
Date Filed:19/07/2002
Date Published:01/06/2004
Assignee:None


 
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