Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6747187

Title:Knockout mouse for the tumor suppressor gene ANX7
Inventors:Srivastava, Meera; Potomac, MD, USA
Pollard, Harvey B.; Potomac, MD, USA
Summary:This invention provides a knockout transgenic mouse containing a nonfunctional allele of the tumor suppressing gene, annexin VII. This transgenic mouse has cells comprising a chromosomally incorporated transgene that comprises a detectable marker sequence, wherein one allele of a genomic Anx VII gene is functionally disrupted by the transgene. The transgenic mouse thus exhibits an increased susceptibility to formation of tumors as compared to a wild type mouse, and the resulting tumors are one or more of insulinoma, hepatocellular carcinoma, and lymphoma of the thymus. This mouse is therefore used as a screening model for potential therapeutic agents useful in the treatment of tumors resulting from an annexin tumor suppressor disease.
Abstract:A knockout transgenic mouse containing a nonfunctional allele of the tumor suppressing gene, annexin VII. This mouse is used as a screening model for potential therapeutic agents useful in the treatment of tumors resulting from an annexin tumor suppressor disease.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6747187
Application Number:US2000000633278
Date Filed:04/08/2000
Date Published:08/06/2004
Assignee:Henry M. Jackson Foundation for The Advancement of Military Medicine, Rockville, MD, USA


 
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