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Stem Cell Related Patent Number US6747187
| Title: | Knockout mouse for the tumor suppressor gene ANX7 | | Inventors: | Srivastava, Meera; Potomac, MD, USA
Pollard, Harvey B.; Potomac, MD, USA | | Summary: | This invention provides a knockout transgenic mouse containing a nonfunctional allele of the tumor suppressing gene, annexin VII. This transgenic mouse has cells comprising a chromosomally incorporated transgene that comprises a detectable marker sequence, wherein one allele of a genomic Anx VII gene is functionally disrupted by the transgene. The transgenic mouse thus exhibits an increased susceptibility to formation of tumors as compared to a wild type mouse, and the resulting tumors are one or more of insulinoma, hepatocellular carcinoma, and lymphoma of the thymus. This mouse is therefore used as a screening model for potential therapeutic agents useful in the treatment of tumors resulting from an annexin tumor suppressor disease. | | Abstract: | A knockout transgenic mouse containing a nonfunctional allele of the tumor suppressing gene, annexin VII. This mouse is used as a screening model for potential therapeutic agents useful in the treatment of tumors resulting from an annexin tumor suppressor disease. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6747187 | | Application Number: | US2000000633278 | | Date Filed: | 04/08/2000 | | Date Published: | 08/06/2004 | | Assignee: | Henry M. Jackson Foundation for The Advancement of Military Medicine, Rockville, MD, USA |
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