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Stem Cell Related Patent Number US6753153
| Title: | Markers for identification and isolation of pancreatic islet .alpha. and .beta. progenitors | | Inventors: | Sarvetnick, Nora; San Diego, CA, USA
Kritzik, Marcie; La Jolla, CA, USA | | Summary: | This invention introduces a method for identifying mammalian pancreatic islet progenitor cells via the detection of the specific markers ErbB2, ErbB3, ErbB4 or Msx-2. Disclosed herein is a method of employing the differential expression of marker proteins in a targeted population as a means of identifying and isolating cells, such that the population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface proteins ErbB2, ErbB3, and ErbB4 and the nuclear protein Msx-2. Therapeutic applications of such populations of isolated pancreatic islet progenitor cells are included, such as in screening assays, in the characterization of genes involved in islet development and regulation, and in the transplantation of pancreatic islet functions. | | Abstract: | The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface proteins ErbB2, ErbB3, and ErbB4; and the nuclear protein Msx-2. Populations of isolated pancreatic islet progenitor cells find use in screening assays, to characterize genes involved in islet development and regulation, and in transplantation to provide a recipient with pancreatic islet functions. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6753153 | | Application Number: | US2000000736911 | | Date Filed: | 13/12/2000 | | Date Published: | 22/06/2004 | | Assignee: | The Scripps Research Institute, La Jolla, CA, USA |
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