Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6753153

Title:Markers for identification and isolation of pancreatic islet .alpha. and .beta. progenitors
Inventors:Sarvetnick, Nora; San Diego, CA, USA
Kritzik, Marcie; La Jolla, CA, USA
Summary:This invention introduces a method for identifying mammalian pancreatic islet progenitor cells via the detection of the specific markers ErbB2, ErbB3, ErbB4 or Msx-2. Disclosed herein is a method of employing the differential expression of marker proteins in a targeted population as a means of identifying and isolating cells, such that the population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface proteins ErbB2, ErbB3, and ErbB4 and the nuclear protein Msx-2. Therapeutic applications of such populations of isolated pancreatic islet progenitor cells are included, such as in screening assays, in the characterization of genes involved in islet development and regulation, and in the transplantation of pancreatic islet functions.
Abstract:The differential expression of marker proteins in a targeted population provides a means of identifying and isolating cells. A population of cells associated with the regeneration of pancreatic islets is shown to express certain proteins, including the cell surface proteins ErbB2, ErbB3, and ErbB4; and the nuclear protein Msx-2. Populations of isolated pancreatic islet progenitor cells find use in screening assays, to characterize genes involved in islet development and regulation, and in transplantation to provide a recipient with pancreatic islet functions.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6753153
Application Number:US2000000736911
Date Filed:13/12/2000
Date Published:22/06/2004
Assignee:The Scripps Research Institute, La Jolla, CA, USA


 
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