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Stem Cell Related Patent Number US6762342
| Title: | Transgenic mice containing intestinal alkaline phosphatase gene disruptions | | Inventors: | Allen, Keith D.; Cary, NC, USA | | Summary: | This invention describes a transgenic mouse resulting from a homozygous disruption in an endogenous intestinal alkaline phosphatase gene. The transgenic mouse thus lacks production of functional intestinal alkaline phosphatase protein and exhibits, relative to a wild-type mouse, abnormal activity level. Such a transgenic mouse is useful as a model for disease and for identifying agents that modulate gene expression and gene function, and as a potential treatment for various disease states and disease conditions. | | Abstract: | The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an intestinal alkaline phosphatase gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US6762342 | | Application Number: | US2001000900708 | | Date Filed: | 06/07/2001 | | Date Published: | 13/07/2004 | | Assignee: | Deltagen, Inc., San Carlos, CA, USA |
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