Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6767531

Title:High dose radionuclide complexes for bone marrow suppression
Inventors:Fritzberg, Alan R.; Olga, WA, USA
Summary:This invention describes a method for the suppression of bone marrow (BM) and the treatment of conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid. Further disclosed are methods for hydrating the patient, as well as methods for administering a dose of 166 Ho-DOTMP to the patient in an aqueous vehicle comprising an effective antiradiolytic amount of a pharmaceutically acceptable radioprotectant, such that the dose delivers approximately 20-60 Gy to the bone marrow of the patient, which is followed by the administration of at least 200 mg/m2 melphalan to the patient, after which the patient is provided with an autologous stem cell transplant, thereby avoiding subjection to total body irradiation.
Abstract:The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6767531
Application Number:US2001000014335
Date Filed:11/12/2001
Date Published:27/07/2004
Assignee:NeoRx Corporation, Seattle, WA, USA


 
Copyright © 2007 The Institute for Cellular Medicine  6/13/2021