Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6767738

Title:Method of isolating adult mammalian CNS-derived progenitor stem cells using density gradient centrifugation
Inventors:Gage, Fred H.; La Jolla, CA, USA
Palmer, Theo; San Carlos, CA, USA
Safar, Francis G.; Irvine, CA, USA
Takahashi, Jun; Kyoto, Japan
Takahashi, Masayo; Kyoto, Japan
Summary:Described herein are methods of producing adult mammalian central nervous system (CNS)-derived progenitor cells or adult mammalian CNS-derived stem cells from adult mammalian CNS tissue. The invention relates to methods of repairing damaged or diseased, specialized or differentiated tissue in mature animals, particularly neuronal tissue such as retinas. In particular, disclosed herein is the transplantation of adult, hippocampus-derived progenitor cells into a selected neural tissue site within a recipient, such that these cells may functionally integrate into mature and immature neural tissue. One embodiment of the invention allows for the repopulation of a retina of a dystrophic animal with neurons via injection of clonally derived, adult CNS-derived stem cells from a healthy donor animal into the eye of the dystrophic recipient. Claims of the invention include the first successful and stable integration of clonally derived adult CNS-derived stem cells into the same-species but with a different strain of recipient. Further disclosed are methods by which the cells were also found to integrate successfully into a xenogeneic recipient. Therapeutic applications emphasize the treatment of opthalmic disorders.
Abstract:The present invention is directed to methods of repairing damaged or diseased, specialized or differentiated tissue in mature animals, particularly neuronal tissue such as retinas. In particular, the invention relates to transplantation of adult, hippocampus-derived progenitor cells into a selected neural tissue site of a recipient. These cells can functionally integrate into mature and immature neural tissue. The invention encompasses, in one aspect, repopulating a retina of a dystrophic animal with neurons, by injecting clonally derived, adult central nervous system derived stem cells (ACSC) derived from a healthy donor animal into an eye of the dystrophic recipient. Herein disclosed is the first successful and stable integration of clonally derived ACSC into same-species but different strain recipients (e. g., Fischer rat-derived adult hippocampal derived progenitor cells (AHPCs) into dystrophic RCS rats). Surprisingly, AHPCs were also found to integrate successfully into a xenogeneic recipient (e.g., rat AHPCs into the retina of dystropic rd-I mice).
US Patent Website:Click Here for Full Text of Patent
Title Number:US6767738
Application Number:US2002000913192
Date Filed:12/02/2002
Date Published:27/07/2004
Assignee:The Salk Institute for Biological Studies, La Jolla, CA, USA


 
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