Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6777233

Title:Cultures of human CNS Neural stem cells
Inventors:Carpenter, Melissa; Foster City, CA, USA
Summary:Described herein are novel neural stem cell cultures. The invention relates to a method for determining the effect of a biological agent via its contacting with the cell culture, such that the cell culture contains a culture medium containing one or more preselected growth factors that are effective for inducing multipotent central nervous system (CNS) neural stem cell proliferation. Further disclosed are methods by which the cell culture contains human multipotent CNS neural stem cells that are suspended in the culture medium and which have been derived from primary CNS neural tissue that exhibits a doubling rate faster than 30 days. In one embodiment of the invention, the cells exhibit a doubling rate of 5 to 10 days. Therapeutic applications are included, such as in the treatment of epilepsy, stroke, Huntington's disease, Alzheimer's disease, multiple sclerosis, and various types of neuropathy.
Abstract:The invention provides a method for determining the effect of a biological agent comprising contacting a cell culture with a biological agent. The cell culture of the invention contains a culture medium containing one or more preselected growth factors effective for inducing multipotent central nervous system (CNS) neural stem cell proliferation. The cell culture also contains, suspended in the culture medium, human multipotent CNS neural stem cells that are derived from primary CNS neural tissue that have a doubling rate faster than 30 days.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6777233
Application Number:US2002000134234
Date Filed:29/04/2002
Date Published:17/08/2004
Assignee:StemCells California, Inc., Palo Alto, CA, USA


 
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