Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US6783977

Title:Internal ribosome entry site and vector containing same
Inventors:Lopez Lastra, Marcelo; Lyons, France
Gabus-Darlix, Caroline; Chaponost, France
Darlix, Jean-Luc; Chaponost, France
Summary:This invention introduces expression vectors containing IRES and/or an encapsidation enhancer derived from a type C retrovirus other than the Friend Murine Leukemia Virus (FMLV) or the Moloney Murine Leukemia Virus (MoMLV). Central to the invention is a nucleotide sequence derived from all or part of the genomic RNA 5' end of a type C retrovirus except for FMLV and MoMLV as an internal ribosome entry site or as an element enabling or improving retrovirus vector packaging. Further disclosed is a vector comprising the nucleotide sequence, a viral particle generated from this vector, a cell comprising this vector or infected by the viral particle, their therapeutic use and a pharmaceutical composition containing them. Methods of transfection are included.
Abstract:The invention concerns the use of a nucleotide sequence derived from all or part of the genomic RNA 5' end of a type C retrovirus except for Friend murine leukaemia virus (FMLV) and Moloney murine leukaemia virus (MoMLV) as internal ribosome entry site or as element enabling or improving retrovirus vector packaging. The invention also concerns a vector comprising said nucleotide sequence, a viral particle generated from this vector, a cell comprising this vector or infected by the viral particle, their therapeutic use and a pharmaceutical composition containing them. The invention further concerns the use of a vector, a viral particle or a pharmaceutical composition for transfecting or infecting pluripotent stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6783977
Application Number:US1999000214124
Date Filed:17/03/1999
Date Published:31/08/2004
Assignee:Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, France


 
Copyright © 2007 The Institute for Cellular Medicine  6/22/2021