Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6797264

Title:Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
Inventors:Eriksson, Peter; Goteborg, Sweden
Summary:Described herein are methods of propagating cells for the treatment of abnormal conditions affecting neural stem cells, progenitor cells and/or cells derived from them via the administration of a substance which induces an increased concentration of growth hormone or a functionally equivalent analogue thereof. Further described is a substance that will increase the release of endogenous growth hormone, for the production of a medicinal product for treatment of abnormal conditions affecting neural stem cells, progenitor cells and/or cells derived from neural stem cells or progenitor cells, especially conditions affecting the oligodendroglia, astroglia, and/or neuronal cells. Also disclosed are in vitro and in vivo methods for inducing lineage determination, and for reducing the genesis of oligodendrocytes, neurons, and astroglial cells from progenitor cells or stem cells, wherein a pharmaceutically effective amount of a substance that will lead to a decreased concentration of growth hormone or a functionally equivalent analogue thereof is administered to the patient.
Abstract:Use of a substance that upon administration will lead to increased concentrations of growth hormone, such as growth hormone, a functionally equivalent analogue thereof or a substance that will increase the release of endogenous growth hormone, for the production of a medicinal product for treatment of abnormal conditions affecting neural stem cells, progenitor cells and/or cells derived from neural stem cells or progenitor cells, especially conditions affecting the oligodendroglia, astroglia, and/or neuronal cells. In vitro and in vivo methods for inducing lineage determination, propagating and/or inducing or maintaining the genesis of neurons, oligodendrocytes, astroglial cells from progenitor cells, stem cells and/or cells derived from said cells by administrating to the cells a substance that increases the concentration of growth hormone. Also a method of reducing the genesis of oligodendrocytes, neurons, astroglial cells from progenitor cells or stem cells, wherein a pharmaceutically effective amount of a substance that will lead to a decreased concentration of growth hormone or a functionally equivalent analogue thereof is administered to said patient.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6797264
Application Number:US2001000856576
Date Filed:13/07/2001
Date Published:28/09/2004
Assignee:Cellartis AB, Goteborg, Sweden


 
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