Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6797816

Title:Identification and cloning of a new subfamily of sulfatases and functional embryonic techniques for characterization of such proteins
Inventors:Emerson, Charles P.; Bala Cynwyd, PA, USA
Dhoot, Gurtej Kaur; London, United Kingdom
Summary:Described herein are novel Sulf-1 and Sulf-2 polypeptides from the subfamily of sulfatases. Claims of the invention include nucleic acid sequences encoding members of this new subfamily of sulfatases and polypeptides encoded thereby. Further disclosed are compositions and methods of modulating sulfatases of this new subfamily to modify growth properties and the differentiation of cells, as well as the ability of cells to prevent viral entry and to prevent recruitment of lymphocytes to a site of inflammation. Therapeutic applications are included, such as in the treatment of cancer by inhibiting metastases, in the treatment of musculoskeletal, neural and renal degenerative disorders, for the inhibition of the viral infection and inflammation of cells, and for the promotion of stem cell differentiation into muscle, neural and renal tissue. Functional embryonic techniques are provided for identification and characterization of developmental regulatory genes such as these sulfatases.
Abstract:Nucleic acid sequences encoding members of a new subfamily of sulfatases and polypeptides encoded thereby are provided. Compositions and methods of modulating sulfatases of this new subfamily to modify growth properties and differentiation of cells, as well as the ability of cells to prevent viral entry and to prevent recruitment of lymphocytes to a site of inflammation are also provided. The compositions and methods are useful in treating cancer and inhibiting metastases, promoting differentiation of stem cells into muscle, neural and renal cells and inhibiting viral infection and inflammation. In addition, functional embryonic techniques for identification and characterization of developmental regulatory genes such as these sulfatases are provided.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6797816
Application Number:US2003000389532
Date Filed:13/03/2003
Date Published:02/09/2004
Assignee:Trustees of the University of Pennsylvania, Philadelphia, PA, USA


 
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