Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6815418

Title:TGF-.alpha. polypeptides, functional fragments and methods of use therefor
Inventors:Twardzik, Daniel R.; Bainbridge Island, WA, USA
Pernet, Andre; Lake Forest, IL, USA
Felker, Thomas S.; Vashon, WA, USA
Paskell, Stefan; Bainbridge Island, WA, USA
Summary:Described herein are ex vivo and in vivo methods of expanding a population of insulin-producing cells in a patient, via the administration of a composition consisting of an effective amount of a TGF-?a57 polypeptide (SEQ ID NO:3). The invention relates to TGF-?a polypeptides, related polypeptides, fragments and mimetics thereof which are useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. Therapeutic applications are included, such as in the treatment of gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular diseases.
Abstract:Disclosed are TGF-.alpha. polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6815418
Application Number:US2001000932172
Date Filed:17/08/2001
Date Published:09/11/2004
Assignee:Kaleidos Pharma, Inc., Seattle, WA, USA


 
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