Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US6821513

Title:Method for enhancing hematopoiesis
Inventors:Fleming, William H.; Portland, OR, USA
Summary:Described herein are methods for enhancing hematopoiesis via transplantation of autologous or heterologous vascular tissue. The invention relates to a method of transplanting at least a therapeutically effective portion of an isolated vascular tissue into a subject, wherein the vascular tissue enhances hematopoiesis. Further disclosed is a method by which an agent that affects hematopoiesis may be detected, which includes treatment of the vascular tissue with the agent, resulting in the detection of hematopoiesis in the subject which is then compared with hematopoiesis in a control. Also provided are a non-human mammalian model, and therapeutic applications in the treatment of vascular diseases.
Abstract:A method is provided for enhancing hematopoiesis. The method includes transplanting at least a therapeutically effective portion of an isolated vascular tissue into a subject, wherein the vascular tissue enhances hematopoiesis. A method is also provided for detecting an agent that affects hematopoiesis. The method includes transplanting a portion of an isolated vascular tissue into a subject, wherein the portion of the isolated vascular tissue is sufficient to enhance hematopoiesis. The vascular tissue is treated with an agent, and hematopoiesis is detected in the subject. Hematopoiesis in the subject is compared with hematopoietic in a control. A change in hematopoiesis in the subject as compared to the control indicatives that the agent affects hematopoiesis. A method is provided for isolating a hematopoiesis growth factor using the method of the invention. In addition, a method is provided for isolating a hematopoietic stem cell using the method of the invention. Pharmaceutical compositions and kits for promoting hematopoiesis are also disclosed. In addition, a non-human animal model is also disclosed for testing agents that affect hematopoiesis. The model system is a non-human animal deficient for hematopoiesis transplanted with an isolated portion of a vascular tissue, wherein the portion of the vascular tissue is sufficient to promote hematopoiesis.
US Patent Website:Click Here for Full Text of Patent
Title Number:US6821513
Application Number:US2001000019165
Date Filed:20/12/2001
Date Published:23/11/2004
Assignee:Oregon Health and Science University, Portland, OR, USA


 
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